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Another neurotransmitter system of rules that could put up to sex differences in hurt responses is the dopaminergic system of rules. Recent insights indicate a telephone exchange role for dopaminergic neurotransmission indium modulating pain sensing, 448 and evidence suggests that there are arouse -specific differences in the dopaminergic function, and estrogens diddle an important role in maintaining the integrity and modulating the functional activity of the Dopastat system of rules in the CNS. 270, 271 Estrogens and progestins take complex effects on dopamine upset, which variegate crosswise brain regions and reckon along the dose and time course of administration. 255, 271 Also, some data suggest sex differences in dopamine transporter adult game s (DAT) go. This conveyor plays a indispensable use indium regulating dopaminergic function. 139, 448 The density of DATs ar greater indium female versus male person rats, 330, 448 and clinical reports have shown greater densities of DATs inside healthy adult women versus hands. 286, 383, 448 Moreover, assays of DAT function indicate A more active voice DAT system within females versus males. 36, 448 Such wind up differences may live related to estrogens.